Strategies for Genetic Studies of Complex Diseases
نویسندگان
چکیده
منابع مشابه
Strategies for Genetic Studies of Complex Diseases
In light of this, it is likely that GWAS hits found in intergenic regions far from known genes are true associations whose biology is not yet understood, rather than false positives. The human genome is incompletely annotated. Regions where GWAS associations have been found, but no known genes are located, could easily harbor unidentified new genes or regulatory elements. For instance, the auth...
متن کاملThe future of genetic studies of complex human diseases.
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متن کاملthe recurrence risk of genetic complex diseases
complex inherited diseases affected by an interaction between collective effects of the genotype at one or multiple loci either to increase or to lower susceptibility to disease, combined with a variety of environmental exposures that may trigger, accelerate, exacerbate, or protect against the disease process. the new aspects of genetic techniques have been opened for diagnosis and analysis of ...
متن کاملGenetic testing for complex diseases
It is widely recognized nowadays that complex diseases are caused by, amongst the others, multiple genetic factors. The recent advent of genome-wide association study (GWA) has triggered a wave of research aimed at discovering genetic factors underlying common complex diseases. While the number of reported susceptible genetic variants is increasing steadily, the application of such findings int...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.07.025